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ONCOGENE PROTEIN P190(BCR-ABL)
Descriptors Found:
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DeCS
Descriptor
English
:
Fusion Proteins, bcr-abl
Descriptor
Spanish
:
Proteínas de Fusión bcr-abl
Descriptor
Portuguese
:
Proteínas de Fusão bcr-abl
Synonyms
English
:
Oncogene Protein p190(bcr-abl)
Oncogene Protein p210(bcr-abl)
bcr-abl Fusion Proteins
Tree Number:
D08.811.913.696.620.682.725.500.500
D12.776.602.500.500.100
D12.776.624.100
D12.776.624.664.500.100
Definition
English
:
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL
GENES
to the genetic locus of the breakpoint cluster region gene on chromosome 22. The p210(bcr-abl) fusion protein is found in
patients
with
LEUKEMIA
, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE. The p190(bcr-abl) fusion protein is found in
patients
with
PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA
. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in
ABELSON MURINE LEUKEMIA VIRUS.
See Related
English
:
Philadelphia Chromosome
History Note
English
:
91; was BCR-ABL FUSION PROTEINS 1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29237
Unique Identifier:
D016044
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
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